art%3A10.1007%2Fs12223-016-0462-y

art%3A10.1007%2Fs12223-016-0462-yBiogenesisofantibiotics—viewingitshistoryandglimpsesofthefutureJ.Spížek1&K.Sigler1&T.Řezanka1&A.Demain2Received:9March2016/Accepted:2May2016/Publishedonline:18May2016#InstituteofMicrobiology,AcademyofSciencesoftheCzechRepublic,v.v.i.2016AbstractThisreviewaimsatcomparingsomehistoricaldatawiththecurrentsituationinthestudyofbiogenesisofnaturalcompounds,antibioticsinthefirstplace.Biogenesisoftetracyclinesandcycloheximideandrelat-edcompoundsservesasexample.Examplesofmolecu-larbiologicalandbioinformaticsmethodsusedinthestudyofantibioticbiogenesisaredescribedbothintermsofitshistoricalaspectsandthecurrentknowledge.IntroductionAlllivingorganismsproduceaplethoraofbiologicallyactivecompounds.Inthisreview,wewillconcentrateonso-calledsecondarymetabolites,i.e.,compoundsthatarenotabsolutelyessentialfortheirproducers;nonpro-ducingmutantsexistthatliveandmultiplywithoutproducingsuchcompounds.Antibioticsbelongtothisgroupofcompounds.Althoughthenumbersareappar-entlyonlyroug