四氧化三铁@二氧化硅（N-异丙基丙烯酸酰胺）

ColloidsandSurfacesB:Biointerfaces102(2013)265–272ContentslistsavailableatSciVerseScienceDirectColloidsandSurfacesB:Biointerfacesjournalhomepage:www.elsevier.com/locate/colsurfbSynthesisofFe3O4@silica/poly(N-isopropylacrylamide)asanovelthermo-responsivesystemforcontrolledreleaseofH3PMo12O40nanodruginACmagneticfieldJavidiJabera,∗,EsmaeilpourMohsenbaInstituteofNanoScienceandNanoTechnology,UniversityofKashan,Kashan,IranbChemistryDepartment,CollegeofScience,ShirazUniversity,Shiraz71454,IranarticleinfoArticlehistory:Received29May2012Receivedinrevisedform14August2012Accepted16August2012Availableonline24August2012Keywords:HeteropolyacidsThermo-responsiveControlledreleaseMagneticfieldNano-drugabstractInthiswork,anewmethodisintroducedforsynthesisofnanodrugforthefirsttime.H3PMo12O40andFe3O4@SiO2/poly(N-isopropylacrylamide),werepreparedasnanodrugandmagnetothermallyresponsivenano-carrierrespectively.ThenthereleasedbehaviorofH3PMo12O40nano-drugfromthisthermo-responsivecarrierwasinvestigatedinanACmagneticfield.Whenadrugparticleisbro-kenuptonanometerrange,thetotalsurfaceareaisincreased;thereforetherateofdissolutionandtherateofreleaseareincreased.Theas-synthesizednanostructureswerecharacterizedbyscan-ningelectronmicroscopy(SEM),X-raypowderdiffraction(XRD),transmissionelectronmicroscopy(TEM),vibratingsamplemagnetometer(VSM),andFouriertransforminfraredspectroscopy(FT-IR).Fur-thermore,experimentalconditionwhichleadtothereleasedprofileofH3PMo12O40nano-drugfromFe3O4@SiO2/poly(N-isopropylacrylamide),suchasstrengthofmagneticfield(H),temperature(T),par-ticlesizeofdrugandcontentofloadeddrugweretested.Increasingthestrengthofmagneticfield,temperatureandcontentofloadeddrug,therateofdrugreleasewasalsoincreased.©2012ElsevierB.V.Allrightsreserved.1.IntroductionHeteropolyacids(HPAs)asclassesofinorganiccompoundaretransitionmetaloxideclustersthatcontainW,MoandVmetals.Thesematerialshaveanimpressiveapplicationpotentialinoptics,electronics,catalysisandmedicines[1–3].Rhuleetal.publishedareviewanddescrib