Incorporation-of-metal-organic-framework-HKUST-1-into-porous-polymer-monolithic-capillary-columns

JournalofChromatographyA,1360(2014)143–149ContentslistsavailableatScienceDirectJournalofChromatographyAjournalhomepage:www.elsevier.com/locate/chromaIncorporationofmetal-organicframeworkHKUST-1intoporouspolymermonolithiccapillarycolumnstoenhancethechromatographicseparationofsmallmoleculesShengchaoYang,FangguiYe∗,QinghuiLv,CongZhang,ShufenShen,ShulinZhaoKeyLaboratoryfortheChemistryandMolecularEngineeringofMedicinalResources(MinistryofEducationofChina),CollegeofChemistryandPharmaceuticalScienceofGuangxiNormalUniversity,Guilin541004,PRChinaarticleinfoArticlehistory:Received5March2014Receivedinrevisedform18June2014Accepted20July2014Availableonline29July2014Keywords:Metal-organicframeworksPolymermonolithCapillaryliquidchromatographyReversedphaseSmallmoleculesabstractMetal-organicframework(MOF)HKUST-1nanoparticleshavebeenincorporatedintopoly(glycidylmethacrylate-co-ethylenedimethacrylate)(HKUST-1-poly(GMA-co-EDMA))monolithstoaffordstation-aryphaseswithenhancedchromatographicperformanceofsmallmoleculesinthereversedphasecapillaryliquidchromatography.TheeffectofHKUST-1nanoparticlesinthepolymerizationmixtureontheperformanceofthemonolithiccolumnwasexploredindetail.Whilethebarepoly(GMA-co-EDMA)monolithexhibitedpoorresolution(Rs<1.0)andlowefficiency(800–16,300plates/m),additionofasmallamountofHKUST-1nanoparticlestothepolymerizationmixtureprovidehighincreasedresolution(Rs≥1.3)andhighefficiencyrangedfrom16,300to44,300plates/m.ChromatographicperformanceofHKUST-1-poly(GMA-co-EDMA)monolithwasdemonstratedbyseparationofvariousanalytesincludingpolycyclicaromatichydrocarbons,ethylbenzeneandstyrene,phenolsandaromaticacidsusingabinarypolarmobilephase(CH3CN/H2O).TheHKUST-1-poly(GMA-co-EDMA)monolithdisplayedenhancedhydrophobicand�–�interactioncharacteristicsinthereversedphaseseparationoftestanalytescomparedtothebarepoly(GMA-co-EDMA)monolith.TheexperimentresultsshowedthatHKUST-1-poly(GMA-co-EDMA)monolithsareanalternativetoenhancethechromatographicseparationofsmallmolecules.©2014ElsevierB.V.Al