慢性HBV感染者外周血CD45RA^+、CD45RO^+T细胞亚群的特点及意义

湖北科技学院学报(医学版)2018年第32卷第6期〔JournalofHubeiUniversityofScienceandTechnology(MedicalSciences)〕479慢性HBV感染者外周血CD45RA+、CD45RO+T细胞亚群的特点及意义刘文婷\姜翠雪\蔡育莹\李静1，杨健1，冯澜(1•佳木斯大学，黑龙江佳木斯154000;2•佳木斯大学附属第一医院）摘要：目的研摘要：目的研究慢性HBVHBV感染者外周血CD8CD8+CD45RACD45RA+T、CD8T、CD8+CD45ROCD45RO+T细胞亚群的特点，探讨二者在慢性HBVHBV感染进程中的作用。方。方法收集7676例慢性HBVHBV感染者，分4组，其中肝功能正常高病毒载量组8例、肝功能异常高病毒载量组2626例、肝功能正常低病毒载量组2626例、肝功能异常低病毒载量组1616例。另收集健康对照组2121例。检测各项指标，统计并分析数据。结。结果与健康对照组相比，慢性HBVHBV感染者组CD8CD8+CD45RACD45RA+T细胞水平较低、CD8CD8+CD45ROCD45RO+T细胞水平较高，差别有统计学差异(P<0.05);(P<0.05);与肝功能异常的慢性HBVHBV感染者组相比，肝功能正常的慢性HBVHBV感染者组CD8CD8+CD45RACD45RA+T水平较高，CD8CD8+CD45ROCD45RO+T水平较低，差别均有统计学意义（P（P均<〇.〇5);<〇.〇5);高病毒载量组与低病毒载量组相比，CD8CD8+CD45RA+TCD45RA+T细胞、CD8CD8+CD45ROCD45RO+T细胞水平均无统计学差异（P（P均>0.05)。结>0.05)。结论慢性HBVHBV感染者外周血CD8CD8+CD45RACD45RA+T细胞可能诱导机体对HBVHBV免疫耐受;CD8+CD45RO+TCD8+CD45RO+T细胞可能诱导机体对HBVHBV免疫清除;慢性HBVHBV感染者胸腺输出功能降低，可能是难以清除HBVHBV感染的重要原因。关键词：肝关键词：肝功能；HBV-DNAHBV-DNA;慢性HBVHBV感染;CD8CD8+CD45RACD45RA+T;CD8T;CD8+CD45R0CD45R0+T中图分类号:R446.113文献标识码:A文章编号=20954646(2018)06-0479-04中图分类号:R446.113文献标识码:A文章编号=20954646(2018)06-0479-04DOI：10.16751/j.cnki.20954646.2018.06.0479DOI：10.16751/j.cnki.20954646.2018.06.0479CharacteristicsandSignificanceofCD45RA+andCD45RO+TLymphocyteSubsetsinPeripheralBloodofPatientswithChronicHBVInfectionLIUWen-Ting,JIANGCui-Xue,FENGLan,etal(JiamusiUniversity,JiamusiHeilongjiang154000yChina)ABSTRACT:ObjectiveTostudythecharacteristicsofCD8+CD45R+TandCD8+CD45RO+TcellsubsetsinperipheralbloodofpatientswithchronicHBVinfectionandtoexploretheirrolesincourseofchronicHBVinfection.Methods76patientswithchronicHBVinfectionwerecollectedanddividedinto4groups.A-mongthem,8caseswerenormalliverfunctionwithhighviralloadgroup,26caseswereabnormalliverfunctionwithhighviralloadgroup,26caseswerenormalliverfunctionwithlowviralloadgroup,16caseswereabnormalliverfunctionwithlowviralloadgroup.Another21caseswerehealthycontrolgroup.ThelevelsofCD8+CD45RA+TcellsandCD8+CD45RO+Tcellsweredetectedandstatisticanalysiswasperformed.ResultsComparewiththehealthycontrolgrou