外周T细胞淋巴瘤患者中PD-1的表达对CD45RA^＋、CD45RO^T细胞的影响

外周T细胞淋巴瘤患者中PD-1的表达对CD45RA+、CD45RO+T细胞的影响吕学文，陈焕伟，徐琼，王博，李晟TherelationshipbetweenPD-1expressionandCD45RA+andCD45R0+Tcellsinpe­ripheralTcelllymphomapatientsLvXuewen,ChenHuanwei,XuQiong,WangBo,LiShengDepartmentofChemotherapy,CentralHospitalofGuangdongProvincialAgriculturalReclamation,GuangdongZhanjiang524002,China.【Abstract】Objective:ToToinvestigateinvestigatethetherelationshiprelationshipbetweenbetweenthetheexpressionexpressionofofPDPD-1ininlymphoidlymphoidtissuetissueandandthethelevellevelofofinitialinitialandandmemorymemoryTcellscellsininperipheralperipheralbloodbloodininperipheralperipheralTcellcelllymphomalymphoma(PTCLPTCL)patientspatients.Methods：TheTheexpressionexpressionofofPDPD-1waswasdetecteddetectedbybyimmunohistochemistryimmunohistochemistryininlymphomalymphomatissuetissueinin20PTCLPTCLpatientspatients.TheTheproportionproportionofofCDCD4+CDCD45RARA+,CDCD4+CDCD45RORO+,CDCD8+CDCD45RARA+andandCDCD8+CDCD45RORO+TcellscellsbeforebeforeandandafterafterCHOPCHOPchemochemo­therapytherapyininperipheralperipheralbloodbloodinin20PTCLPTCLpatientspatientswereweredetecteddetectedbybyflowflowcytometrycytometry.TheTherelationshiprelationshipbetweenbetweenexpressionexpressionofofPDPD-1andandTcellcellsubsetssubsetswaswasanalysedanalysed.Results：TheTheexpressionexpressionofofPDPD-1andandPDPD-LILIproteinproteinwerewereincreasedincreasedininPTCLPTCLpatientspatients,andandPDPD-1positivepositivepatientspatientshadhadpoorpoorcurativecurativeeffecteffect.TheTheCDCD4+TcellscellsandandCDCD8+TcellscellsininPDPD-1positivepositivepatientspatientswereweresignificantlysignificantlylowerlowerthanthanthatthatofofPDPD-1negativenegativegroupgroup.TheTheCDCD4+CDCD45RORO+,CDCD8+CDCD45RARA+andandCDCD8+CDCD45RORO+TcellscellsininthethePDPD-1negativenegativegroupgroupwereweresignificantlysignificantlyhigherhigherthanthanthosethoseininthethePDPD-1positivepositivegroupgroup,thethedifferencedifferencewaswasstatisticallystatisticallysignificantsignificant.Conclusion：TheTheexpressionexpressionofofPDPD-1/PD/