（英文文献）1-s2.0-S1353802009706893-main
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2019-03-19 09:47:07
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1-s2.0-S1353802009706893-mainS180Posterpresentations/ParkinsonismandRelatedDisorders15S2(2009)S29–S199sameTBSprotocolwithoutL-dopa.cTBScomprisedof3pulsesat50Hzrepeatedat5Hzcontinuouslytodeliver600pulses.RepeatedmeasuresANOVAwasusedtocomparetheeffects.TheeffectofiTBSwastestedimmediatelyafteritandat10-minuteintervalsfor30minutes.Results:Controlsubjectsshoweda43%decrementintheMEPfromFDImusclewhilePDpatientsshowedonly20%reductionlastingonlyfor10min.Therewassonosignificantdifferencebetweenthe2sidesofthebrain.TherewasatrendforfurtherreductionofinhibitoryplasticitywithL-dopa.Conclusions:InhibitoryplasticityofbrainappearstobeimpairedinearlyuntreatedPDonbothsidesofthebrainandisfurtherreducedbyasingledoseofL-dopa.P3.124Redoxdrivenapoptoticsignalingunderlies’selectivityvulnerability’inanimalmodelofParkinson’sdiseaseS.Karunakaran,V.Ravindranath.DivisionofMolecularandCellularNeurosciences,NationalBrainResearchCentre,Manesar,IndiaParkinson’sdisease(PD)ischaracterizedbythelossofdopaminergicneuronsins
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