45-Novel soil bacteria possess diverse genes for s

45-Novel soil bacteria possess diverse genes for secondary metabolite biosynthesisLetterhttps://doi.org/10.1038/s41586-018-0207-yNovelsoilbacteriapossessdiversegenesforsecondarymetabolitebiosynthesisAlexanderCrits-Christoph1,2,SpencerDiamond3,CristinaN.Butterfield3,BrianC.thomas3&JillianF.Banfield2,3,4,5*Insoilecosystems,microorganismsproducediversesecondarymetabolitessuchasantibiotics,antifungalsandsiderophoresthatmediatecommunication,competitionandinteractionswithotherorganismsandtheenvironment1,2.Mostknownantibioticsarederivedfromafewculturablemicrobialtaxa3,andthebiosyntheticpotentialofthevastmajorityofbacteriainsoilhasrarelybeeninvestigated4.Herewereconstructhundredsofnear-completegenomesfromgrasslandsoilmetagenomesandidentifymicroorganismsfrompreviouslyunderstudiedphylathatencodediversepolyketideandnonribosomalpeptidebiosyntheticgeneclustersthataredivergentfromwell-studiedclusters.ThesebiosyntheticlociareencodedbynewlyidentifiedmembersoftheAcidobacteria,VerrucomicobiaandGemmatimo