54 Genetic correlation network prediction of fores

54 Genetic correlation network prediction of forest soil microbial functional organization.TheISMEJournal(2018)12:2492–2505https://doi.org/10.1038/s41396-018-0232-8ARTICLEGeneticcorrelationnetworkpredictionofforestsoilmicrobialfunctionalorganizationBinMa1,2●KankanZhao1,2●XiaofeiLv1,2●WeiqinSu1,2●ZhongminDai1,2●JackA.Gilbert3,4●PhilipC.Brookes1,2●KarolineFaust5●JianmingXu1,2Received:9April2018/Revised:11June2018/Accepted:15June2018/Publishedonline:25July2018©TheAuthor(s)2018.ThisarticleispublishedwithopenaccessAbstractSoilecologicalfunctionsarelargelydeterminedbytheactivitiesofsoilmicroorganisms,which,inturn,areregulatedbyrelevantinteractionsbetweengenesandtheircorrespondingpathways.Therefore,thegeneticnetworkcantheoreticallyelucidatethefunctionalorganizationthatsupportscomplexmicrobialcommunityfunctions,althoughthishasnotbeenpreviouslyattempted.Wegeneratedageneticcorrelationnetworkbasedon5421genesderivedfrommetagenomesofforestsoils,identifying7191positiveand123negativecorrelationrelati