71 Urban park soil microbiomes are a rich reservoi

71 Urban park soil microbiomes are a rich reservoir of natural product biosynthetic diversity.UrbanparksoilmicrobiomesarearichreservoirofnaturalproductbiosyntheticdiversityZacharyCharlop-Powersa,ClaraC.Pregitzerb,ChristopheLemetrea,MelindaA.Terneia,JeffreyManikoa,BradleyM.Hovera,PaulaY.Callea,KristaL.McGuirec,d,JeanneGarbarinoe,HelenM.Forgioneb,SarahCharlop-Powersb,andSeanF.Bradya,1aLaboratoryofGeneticallyEncodedSmallMolecules,TheRockefellerUniversity,NewYork,NY10065;bNaturalAreasConservancy,NewYork,NY10029;cDepartmentofBiology,BarnardCollege,ColumbiaUniversity,NewYork,NY10027;dDepartmentofEcology,EvolutionandEnvironmentalBiology,ColumbiaUniversity,NewYork,NY10027;andeScienceOutreachProgram,TheRockefellerUniversity,NewYork,NY10065EditedbyJerroldMeinwald,CornellUniversity,Ithaca,NY,andapprovedOctober20,2016(receivedforreviewSeptember17,2016)Numeroustherapeuticallyrelevantsmallmoleculeshavebeeniden-tifiedfromthescreeningofnaturalproducts(NPs)producedbyenvironmentalbacteria.Thesediscovery