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QQuartzcrystalmicrobalance559●QQQCM�quartzcrystalmicrobalanceQCN�quartzcrystalmicrobalanceQuadraticmean�rootmeansquareQuantitationlimit�limitofquantitationQuartzcrystalmicrobalance—Thequartzcrys-talmicrobalance(QCM)ornanobalance(QCN)isathickness-shear-modeacousticwavemass-sensitivedetectorbasedontheeffectofanattachedforeignmassontheresonantfrequencyofanoscillatingquartzcrys-tal.TheQCMrespondstoanyinterfacialmasschange.TheresponseofaQCMisalsoextremelysensitivetothemass(density)andviscoelasticchangesatthesolid-solutioninterface[i–vi].Itisapiezoelectric(�piezoelectricity)sensingdevicethatconsistofanoscillatorcircuitandacrystalwhichisincorporatedintothefeedbackloopofthecircuit.Thecrystalisthefrequency-determiningelement,asitsqualityfactorisveryhigh.Thepiezoelectriccrystalsarepatternedwithtwoexci-tationelectrodes(electronicsurfacefilms)ontheirop-positesides.Duetotheconversepiezoelectricityphe-nomenon,when�alternatingvoltageisappliedtotheattachedelectrodesmechanicaloscillationsoccurwithinthe

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