环胞苷二棕榈酸酯脂质体粒度分布及微黏度的测定_王继波

环胞苷二棕榈酸酯脂质体粒度分布及微黏度的测定_王继波第23卷第2期2006年2月精细化工FINECHEMICALSVol.23,No.2Feb.2006医药与日化原料环胞苷二棕榈酸酯脂质体粒度分布及微黏度的测定＊王继波(青岛大学医学院药学系,山东青岛266021)摘要:对环胞苷二棕榈酸酯脂质体的物理稳定性进行了评价。用反相蒸发法制备环胞苷二棕榈酸酯脂质体,将其与空白脂质体对照,分别测定了它们受热前后的粒度分布及微黏度。结果表明,经37℃,40h温育后其平均粒径仅增加了0.54μm,而空白脂质体增加了1.35μm。环胞苷二棕榈酸酯脂质体的微黏度比空白脂质体提高了近一倍。环胞苷二棕榈酸酯载于脂质体上提高了脂质体的物理稳定性。关键词:环胞苷二棕榈酸酯;脂质体;粒度分布;微黏度中图分类号:TQ577.77文献标识码:A文章编号:1003-5214(2006)02-0154-04MeasurementofSizeDistributionandMicroviscosityofDipalmitoylCyclocytidineLiposomeWANGJi-bo(DepartmentofPharmacy,MedicalCollegeofQingdaoUniversity,Qingdao266021,Shandong,China)Abstract:Physicalstabilityofdipalmitoylcyclocytidine(DPCC)liposomewasevaluated.DPCCliposomewaspreparedbyreversephaseevaporationmethod.Comparedwithblankliposome,thesizedistributionandmicroviscosityofDPCCliposomeweremeasured.ResultsshowedthatthemeanparticlediameterofDPCCliposomechangedonly0.52μmafterheatingunder37℃for40h,whilethevalueofblankliposomewas1.35μm.ThemicroviscosityofDPCCliposomewasabout2timesashighasthatofblankliposome.DPCC